Lessons from Sicilian centenarians for anti-ageing medicine. The Oxi-inflammatory status

Authors

Calogero Caruso, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, ItalyFollow
Giulia Accardi, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
Anna Aiello, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
Anna Calabrò, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
Mattia Emanuela Ligotti, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
Giuseppina Candore, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy

Abstract

Population ageing is a great achievement of humanity, but it also represents a challenge that the Western world is currently facing, as ageing is associated with increased susceptibility to age-related inflammatory diseases. Therefore, it is necessary to fully understand the mechanisms of healthy ageing to prevent the harmful aspects of ageing. The study of long living ndividuals (LLIs) is a great model for trying to achieve this goal. Accordingly, the oxy-inflammatory status of Sicilian LLIs was reviewed in the present paper. Based on the reported data, anti-inflammatory and anti-oxidative stress strategies have been discussed, useful for delaying or avoiding the onset of age-related diseases, thus favouring a healthy ageing process.

Recommended Citation

Caruso, Calogero; Accardi, Giulia; Aiello, Anna; Calabrò, Anna; Ligotti, Mattia Emanuela; and Candore, Giuseppina (2022) "Lessons from Sicilian centenarians for anti-ageing medicine. The Oxi-inflammatory status," Translational Medicine @ UniSa: Vol. 24 : Iss. 2 , Article 3.
Available at: https://doi.org/10.37825/2239-9747.1036

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